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Symbol Name ID |
Ctnnb1
catenin beta 1 MGI:88276 |
| Darker colors indicate more annotations |
| Human Phenotypes | Cerebellar hemorrhage |
Primary microcephaly |
Dysphagia |
Spasticity |
Spastic diplegia |
Progressive spasticity |
Cerebellar calcifications |
Abnormal cranial nerve morphology |
Hydrocephalus |
Hypoplasia of the corpus callosum |
Cerebellar cyst |
Spinal cord tumor |
Medulloblastoma |
Cerebellar medulloblastoma |
Neuroblastoma |
Ataxia |
Cerebellar ataxia associated with quadrupedal gait |
Dysmetria |
Progressive cerebellar ataxia |
Intention tremor |
Increased intracranial pressure |
Irritability |
Lethargy |
Autistic behavior |
Aggressive behavior |
Restlessness |
Self-mutilation |
Cognitive impairment |
Intellectual disability |
Abnormal brain FDG positron emission tomography |
Headache |
Global developmental delay |
Delayed ability to crawl |
Delayed ability to sit |
Delayed ability to walk |
| Disease(s) Associated with CTNNB1 | |||||||||||||||||||||||||||||||||||
| autosomal dominant intellectual developmental disorder 19 | |||||||||||||||||||||||||||||||||||
| medulloblastoma |
| Mouse Phenotypes | increased susceptibility to pharmacologically induced seizures |
seizures |
intracranial hemorrhage |
spinal hemorrhage |
abnormal blood-brain barrier function |
abnormal neuron differentiation |
premature neuronal precursor differentiation |
abnormal neural tube morphology |
abnormal melanoblast morphology |
abnormal adenohypophysis morphology |
increased corticotroph cell number |
decreased gonadotroph cell number |
absent lactotrophs |
absent somatotrophs |
absent thyrotrophs |
small adenohypophysis |
absent pituitary gland |
increased pituitary gland tumor incidence |
abnormal nervous system morphology |
abnormal brain morphology |
abnormal brain development |
abnormal forebrain development |
abnormal telencephalon development |
absent midbrain-hindbrain boundary |
forebrain hypoplasia |
decreased brain size |
increased brain size |
dilated lateral ventricle |
absent choroid plexus |
decreased corpus callosum size |
absent corpus callosum |
absent hippocampal commissure |
abnormal midbrain morphology |
abnormal trigeminal V mesencephalic nucleus morphology |
absent midbrain |
abnormal globus pallidus morphology |
increased striatum size |
enlarged thalamus |
abnormal hippocampus morphology |
absent hippocampus CA1 region |
absent hippocampus CA2 region |
absent hippocampus CA3 region |
absent dentate gyrus |
abnormal hippocampus neuron morphology |
abnormal telencephalon morphology |
abnormal cerebral cortex morphology |
small olfactory bulb |
abnormal hindbrain morphology |
absent cerebellum |
small cerebellum |
absent metencephalon |
decreased motor neuron number |
abnormal cranial nerve morphology |
abnormal facial nerve morphology |
abnormal glossopharyngeal nerve morphology |
abnormal hypoglossal nerve morphology |
absent oculomotor nerve |
abnormal vagus nerve morphology |
abnormal dorsal root ganglion morphology |
abnormal spinal cord medial motor column morphology |
decreased spinal cord size |
increased spinal cord size |
abnormal neuron physiology |
abnormal synaptic vesicle clustering |
reduced long-term potentiation |
decreased prepulse inhibition |
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| Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Ctnnb1tm1Kba/Ctnnb1tm1Kba | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Ctnnb1Bfc/Ctnnb1+ | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Tg(Dct-lacZ)A12Jkn/0 Tg(Tyr-Ctnnb1/EGFP)#Lru/0 |
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| Ctnnb1tm1Mmt/Ctnnb1tm1Mmt Tg(Pitx1-cre)7Rsd/0 (conditional) |
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| Ctnnb1tm2Kem/Ctnnb1tm2Kem Emx1tm1(cre)Yql/Emx1+ (conditional) |
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| Ctnnb1tm2Kem/Ctnnb1tm2Kem Tg(Pitx1-cre)7Rsd/0 (conditional) |
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| Ctnnb1tm2Kem/Ctnnb1tm2Kem Olig2tm1(cre)Tmj/Olig2+ (conditional) |
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| Ctnnb1tm2Kem/Ctnnb1tm2Kem H2az2Tg(Wnt1-cre)11Rth/H2az2+ (conditional) |
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| Ctnnb1tm2Kem/Ctnnb1tm2Kem Pvalbtm1(cre)Arbr/Pvalb+ (conditional) |
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| Ctnnb1tm2Kem/Ctnnb1tm2Kem Tg(Dct-lacZ)A12Jkn/0 Tg(Tyr-cre)1Lru/0 (conditional) |
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| Ctnnb1tm4Wbm/Ctnnb1tm4Wbm Tg(Pou3f4-cre)32Cren/? (conditional) |
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| Ctnnb1tm4Wbm/Ctnnb1tm4Wbm Pax3tm1(cre)Joe/Pax3+ (conditional) |
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| Ctnnb1tm1Mmt/Ctnnb1+ Tg(Pou3f4-cre)32Cren/? (conditional) |
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| Ctnnb1tm1Mmt/Ctnnb1+ Sox2tm1.1(cre/ERT2)Jpmb/Sox2+ (conditional) |
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| Ctnnb1tm2Kem/Ctnnb1tm2.1Kem H2az2Tg(Wnt1-cre)11Rth/H2az2+ (conditional) |
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| Ctnnb1tm2Kem/Ctnnb1tm2.1Kem Kdrtm1(cre)Sato/Kdr+ (conditional) |
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| Ctnnb1tm2Kem/Ctnnb1tm3Kba H2az2Tg(Wnt1-cre)11Rth/H2az2+ (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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